' 
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 17 Reviews
8.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Folate may protect against OSA
The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study.
Folate's impact on sleep apnea
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
Read More
Most Useful Reviews
9.5
Improved sleep quality
After giving birth, I suffered from fatigue and discomfort in my legs, especially at night. Following a recommendation, I began taking this supplement, and almost immediately, my leg pain and sleeplessness improved. My sleep became noticeably better, though I still feel there might be some deficiency.
Read More
9.5
Improved sleep quality
Taking methylfolate has significantly improved my sleep quality and increased my haemoglobin levels in blood tests. I appreciate this natural form of folic acid as it’s taken once a day, doesn't cause allergies or side effects, and is crucial for pregnancy planning and maintaining beauty. I strongly recommend all women consider periodic courses of methylfolate to address deficiencies and preserve youth.
Read More
9.5
Addressed sleep apnea
My family has high homocysteine levels, which can lead to sleep apnea and anxiety. After just three days on 5-MTHF, I noticed significant improvements in my sleep. I now sleep through the night.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
8
Folate may protect against OSA
The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study.
Folate's impact on sleep apnea
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.
This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.
Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.8
10
Restored sleep hours
After suffering from insomnia for a year due to B9 deficiency, taking methyl folate has been life-changing. I now enjoy 9 hours of sleep daily, a stark contrast to my previous 3-5 hours.
9.5
Improved sleep quality
After giving birth, I suffered from fatigue and discomfort in my legs, especially at night. Following a recommendation, I began taking this supplement, and almost immediately, my leg pain and sleeplessness improved. My sleep became noticeably better, though I still feel there might be some deficiency.
Read More
9.5
Improved sleep quality
Taking methylfolate has significantly improved my sleep quality and increased my haemoglobin levels in blood tests. I appreciate this natural form of folic acid as it’s taken once a day, doesn't cause allergies or side effects, and is crucial for pregnancy planning and maintaining beauty. I strongly recommend all women consider periodic courses of methylfolate to address deficiencies and preserve youth.
Read More
9.5
Addressed sleep apnea
My family has high homocysteine levels, which can lead to sleep apnea and anxiety. After just three days on 5-MTHF, I noticed significant improvements in my sleep. I now sleep through the night.
9.5
Increased productivity
I bought this for my husband, who has taken it for over six months. He has become stronger and sleeps better, allowing him to be more productive. His doctor has recommended continuing the treatment, so I purchased methylfolate again.
