Last update
4/4/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
USERS' SCORE
Good
Based on 14 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
7
Folic acid linked to OSA severity
We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
Read More
9.5
Weight loss resolves sleep apnea
We examined the effects of bariatric surgery on children aged 8 to 18 facing severe obesity. The study involved 22 children, half of whom had sleep apnea.
Remarkably, children with sleep apnea experienced a significant drop in BMI after surgery, leading to the resolution of their sleep difficulties.
Additionally, many reported improvements in school performance and overall quality of life. While there were a few postoperative complications, the surgeries were deemed safe, promoting the idea that similar interventions can benefit severely obese children.
Remarkably, children with sleep apnea experienced a significant drop in BMI after surgery, leading to the resolution of their sleep difficulties.
Additionally, many reported improvements in school performance and overall quality of life. While there were a few postoperative complications, the surgeries were deemed safe, promoting the idea that similar interventions can benefit severely obese children.
Read More
Most Useful Reviews
9
Improved sleep quality
21 people found this helpful
After giving birth, I suffered from fatigue and discomfort in my legs, especially at night. Following a recommendation, I began taking this supplement, and almost immediately, my leg pain and sleeplessness improved. My sleep became noticeably better, though I still feel there might be some deficiency.
Read More
9
Improved sleep quality
19 people found this helpful
Taking methylfolate has significantly improved my sleep quality and increased my haemoglobin levels in blood tests. I appreciate this natural form of folic acid as it’s taken once a day, doesn't cause allergies or side effects, and is crucial for pregnancy planning and maintaining beauty. I strongly recommend all women consider periodic courses of methylfolate to address deficiencies and preserve youth.
Read More
9
Enhanced sleep patterns
1 people found this helpful
Inositol has greatly improved my sleep quality, allowing me to sleep through the night without waking up. It has truly contributed to achieving long and healthy sleep.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
- All Researches
9.5
Weight loss resolves sleep apnea
We examined the effects of bariatric surgery on children aged 8 to 18 facing severe obesity. The study involved 22 children, half of whom had sleep apnea.
Remarkably, children with sleep apnea experienced a significant drop in BMI after surgery, leading to the resolution of their sleep difficulties.
Additionally, many reported improvements in school performance and overall quality of life. While there were a few postoperative complications, the surgeries were deemed safe, promoting the idea that similar interventions can benefit severely obese children.
Remarkably, children with sleep apnea experienced a significant drop in BMI after surgery, leading to the resolution of their sleep difficulties.
Additionally, many reported improvements in school performance and overall quality of life. While there were a few postoperative complications, the surgeries were deemed safe, promoting the idea that similar interventions can benefit severely obese children.
Read More
7
Folic acid linked to OSA severity
We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved sleep quality
21 people found this helpful
After giving birth, I suffered from fatigue and discomfort in my legs, especially at night. Following a recommendation, I began taking this supplement, and almost immediately, my leg pain and sleeplessness improved. My sleep became noticeably better, though I still feel there might be some deficiency.
Read More
9
Improved sleep quality
19 people found this helpful
Taking methylfolate has significantly improved my sleep quality and increased my haemoglobin levels in blood tests. I appreciate this natural form of folic acid as it’s taken once a day, doesn't cause allergies or side effects, and is crucial for pregnancy planning and maintaining beauty. I strongly recommend all women consider periodic courses of methylfolate to address deficiencies and preserve youth.
Read More
9
Enhanced sleep patterns
1 people found this helpful
Inositol has greatly improved my sleep quality, allowing me to sleep through the night without waking up. It has truly contributed to achieving long and healthy sleep.
Read More
9
Deep sleep impact
1 people found this helpful
This folic acid has given me energy and significantly improved my sleep quality. Its effectiveness is impressive, and it has no taste or smell, making it easy to incorporate into my daily routine.
Read More
7.5
Reduced hormonal issues
7 people found this helpful
After nearly finishing the first package, my well-being has improved significantly; I don’t get hot, and I sleep well at night. I would recommend this product to women experiencing hormonal discomfort. I'm ordering another package.
Read More
Frequently Asked Questions
7.5
Reduced hormonal issues
7 people found this helpful
After nearly finishing the first package, my well-being has improved significantly; I don’t get hot, and I sleep well at night. I would recommend this product to women experiencing hormonal discomfort. I'm ordering another package.
8
Effective sleep improvement
I began taking methylfolate for two months alongside iron preparations. It has notably improved my deep sleep and increased my haemoglobin levels. I highly recommend it, particularly for its digestibility and synergy with beauty and youth preservation.
6
Eased leg discomfort
4 people found this helpful
The capsules are small and easy to swallow. I have sleep issues related to nerves and blood vessels, and since taking Methylfolate, my restless leg symptoms have disappeared. I hope they do not return once I stop.
9
Improved sleep quality
19 people found this helpful
Taking methylfolate has significantly improved my sleep quality and increased my haemoglobin levels in blood tests. I appreciate this natural form of folic acid as it’s taken once a day, doesn't cause allergies or side effects, and is crucial for pregnancy planning and maintaining beauty. I strongly recommend all women consider periodic courses of methylfolate to address deficiencies and preserve youth.
7.5
Restored sleep routine
15 people found this helpful
For years, I struggled with sleep maintenance issues until I started taking zinc, methyl folic acid, and magnesium. Now, I can sleep for six hours straight, and my overall quality of life has improved significantly.
7
Better sleep
3 people found this helpful
Methylfolate enhances sleep, appetite, and mood while improving metabolism and balancing the nervous system. It is absorbed faster than ordinary folic acid, leading to quicker results. Highly recommended for those who care about their health.
7
Folic acid linked to OSA severity
We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
9.5
Weight loss resolves sleep apnea
We examined the effects of bariatric surgery on children aged 8 to 18 facing severe obesity. The study involved 22 children, half of whom had sleep apnea.
Remarkably, children with sleep apnea experienced a significant drop in BMI after surgery, leading to the resolution of their sleep difficulties.
Additionally, many reported improvements in school performance and overall quality of life. While there were a few postoperative complications, the surgeries were deemed safe, promoting the idea that similar interventions can benefit severely obese children.
Remarkably, children with sleep apnea experienced a significant drop in BMI after surgery, leading to the resolution of their sleep difficulties.
Additionally, many reported improvements in school performance and overall quality of life. While there were a few postoperative complications, the surgeries were deemed safe, promoting the idea that similar interventions can benefit severely obese children.
References
- Chrysostomou S, Frangopoulos F, Koutras Y, Andreou K, Socratous L, et al. The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study. PLoS One. 2022;17:e0265148. 10.1371/journal.pone.0265148
- Breaux CW. Obesity Surgery in Children. Obes Surg. 1995;5:279. PubMed
Data last updated:
